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Cocaine dependence (or addiction) is psychological dependency on the regular use of cocaine. Cocaine dependency can result in physiological damage, lethargy, psychosis, depression, akathisia, and fatal overdose. Common signs of snorting cocaine, the most popular method of ingestion, includeloss of the sense of smell, nosebleeds, difficulty swallowing, hoarseness, and a chronically runny nose. Methamphetamine is known to have a high potential for abuse and addiction. Recreational use of methamphetamine may result in psychosis or lead to post-withdrawal syndrome, a withdrawal syndrome that can persist for months beyond the typical withdrawal period. Unlike amphetamine, methamphetamine is neurotoxic to humans, damaging both dopamine and serotonin neurons in the CNS. There is evidence that methamphetamine causes brain damage from long term use in humans; this damage includes adverse changes in brain structure and function, such as reductions in gray matter volume in several brain regions a...