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CT scan of the head without contrast diagnosed as Lyme disease. There are areas of low attenuation within the white matter in the right parietal region, (shown here), and in the periventricular white matter around the occipital horn of the right lateral ventricle, (not shown). The patient was an 18 year old African-American woman with a 4 week history of fatigue, diffuse muscle and joint pain, and recent onset of headache and stiff neck. One week earlier she developed a blind spot in her left eye. Immunological testing showed Lyme disease.