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metal prints aids metal prints aids virus metal prints binding site metal prints catalytic site metal prints dna metal prints enzyme metal prints hiv metal prints immunodeficiency metal prints inactivation metal prints inhibitor metal prints molecule metal prints nucleotide metal prints protein metal prints retrovirus metal prints reverse transcriptase metal prints

photographs aids photos aids virus photos binding site photos catalytic site photos dna photos enzyme photos hiv photos immunodeficiency photos inactivation photos inhibitor photos molecule photos nucleotide photos protein photos retrovirus photos reverse transcriptase photos

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HIV-1 reverse transcriptase (RT) complexed with two different inhibitors. Left RT with a 30 nucleoside inhibitor (orange), right RT with a non nucleoside inhibitor (yellow). The human immunodeficiency virus single-stranded RNA genome is converted into double-stranded DNA by the viral reverse transcriptase and then the DNA is integrated in the DNA of an infected human cell. The reverse transcriptase is one of the main targets to disrupt the virus multiplication through an inhibitor. There are nucleoside and nucleotide inhibitors and non nucleoside analogue inhibitors.