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t-shirts illustration t-shirts diagram t-shirts chart t-shirts allergy t-shirts allergen t-shirts allergic reaction t-shirts antigen t-shirts bee sting t-shirts wasp sting t-shirts venom t-shirts immunology t-shirts immune system t-shirts immunity t-shirts white blood cell t-shirts dendritic cell t-shirts

photographs illustration photos diagram photos chart photos allergy photos allergen photos allergic reaction photos antigen photos bee sting photos wasp sting photos venom photos immunology photos immune system photos immunity photos white blood cell photos dendritic cell photos

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An illustration of allergy sensitization, the process in which allergies develop after initial exposure to an antigen. In this example, the sting from a wasp exposes the body to antigens (green) which are absorbed by dendritic cells in the immune system. Dendritic cells act as antigen presenting cells, binding to T cells using MHC2, TCR, and CD4 receptors. Activated T cells differentiate into helper T cells, which release cytokines. Cytokines stimulate plasma cells to synthesize IgE antibodies that are specific to the foreign antigen. The IgE antibodies bind to mast cells in the immune system and circulate in the blood. During a future exposure, mast cells with IgE antibodies on it's surface bind to the antigens and release histamine, a chemical mediator that causes inflammation.