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Boundary: Bleed area may not be visible.
by Evan Oto
$15.00
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Product Details
Our spiral notebooks are 6" x 8" in size and include 120 pages which are lined on both sides. The artwork is printed on the front cover which is made of thick paper stock, and the back cover is medium gray in color. The inside of the back cover includes a pocket for storing extra paper and pens.
Design Details
An illustration of allergy sensitization, the process in which allergies develop after initial exposure to an antigen. In this example, the sting... more
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An illustration of allergy sensitization, the process in which allergies develop after initial exposure to an antigen. In this example, the sting from a wasp exposes the body to antigens (green) which are absorbed by dendritic cells in the immune system. Dendritic cells act as antigen presenting cells, binding to T cells using MHC2, TCR, and CD4 receptors. Activated T cells differentiate into helper T cells, which release cytokines. Cytokines stimulate plasma cells to synthesize IgE antibodies that are specific to the foreign antigen. The IgE antibodies bind to mast cells in the immune system and circulate in the blood. During a future exposure, mast cells with IgE antibodies on it's surface bind to the antigens and release histamine, a chemical mediator that causes inflammation.
$15.00
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