Cell Death Wave Using C Dots
by Science Source
Title
Cell Death Wave Using C Dots
Artist
Science Source
Medium
Photograph - Photograph
Description
Carbon quantum dots (C dots) are nanoparticles less than 10 nanometers in size. Biomedical researchers are exploring ways to use C dots as drug carriers, fluorescent tags, and more. This image shows cells from a mouse model of melanoma (B16) after treatment with high-dose, melanoma-targeted C dots carrying a therapeutic agent peptides targeting the melanocortin-1 receptor. After treatment, cancer cells (upper left panel) die by an iron-driven mechanism called ferroptosis (upper right panel, green). This results in death spreading through the cells in a wave-like manner. The lower panel shows the cell death wave, with individual nuclei pseudocolored to represent the relative timing of cell death. A nanometer is a billionth of a meter (the head of a pin is about a million nanometers across). Nanoscale materials and devices can interact readily, and in novel ways, with biomolecules both on the surface and inside of cells. 2017 NCI Cancer Close Up project.
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August 6th, 2018
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