Nanoclusters In Breast Tumor
by Science Source
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Nanoclusters In Breast Tumor
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Science Source
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Nanoclusters are made when different nanoparticles and agents are linked together. Gold nanoparticles were linked to a short protein (DAPTA peptide) that binds to C-C chemokine receptor type 5 (CCR5), as well as a PET imaging agent, 64Cu. CCR5 has been identified as a biomarker for triple-negative breast cancer. This PET/CT image of the targeted gold nanocluster (64Cu-AuNCs-DAPTA) was acquired 24 hours after intravenous injection in a mouse model of triple-negative breast cancer. The image shows specific tumor accumulation of the nanoclusters (left side, contrast area). A nanometer is a billionth of a meter (the head of a pin is about a million nanometers across). Nanoscale materials and devices can interact readily, and in novel ways, with biomolecules both on the surface and inside of cells. 2017 NCI Cancer Close Up project.
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August 6th, 2018
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